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Abstract
Purpose: This study was performed to compare the positive predictive value of peripapillary retinal nerve fiber layer (RNFL) thickness measurements obtained using Cirrus high-definition optical coherence tomography (Cirrus HD-OCT; Carl Zeiss Meditec, Dublin, CA) and spectral OCT/scanning laser ophthalmoscopy (SLO) (OPKO/OTI, Miami, FL) in the diagnosis of glaucoma.
Methods: A total of 50 eyes of 50 healthy subjects and 60 eyes of 60 subjects with glaucoma were included. All participants underwent RNFL thickness measurement using Cirrus HD-OCT and spectral OCT/SLO on the same day. Average, quadrant, clock-hour RNFL thicknesses, area under the receiver operating characteristic curve (AUC), and sensitivities at fixed specificities (80% and 95%) were calculated for comparison.
Results: RNFL thickness as measured by spectral OCT/SLO was greater than that measured using Cirrus HD-OCT (p < 0.001). For both the Cirrus HD-OCT and spectral OCT/SLO, the parameter with the largest AUC was average RNFL thickness (0.954 and 0.944, respectively). The AUCs of RNFL thickness for the discrimination of glaucoma did not differ significantly between the devices (p > 0.05), with the exception of RNFL thickness in the nasal area (nasal quadrant, clock-hour sectors 3 and 4); in these areas, spectral OCL/SLO yielded greater AUCs than Cirrus HD-OCT (p < 0.05). Sensitivities varied similarly to AUCs.
Conclusions: RNFL thicknesses measures using Cirrus HD-OCT and spectral OCT/SLO were not interchangeable. The utility of RNFL thickness measurements in the diagnosis of glaucoma was similar for both the devices.