Reproducibility of Angle Metrics Using the Time-Domain Anterior Segment Optical Coherence Tomography: Intra-Observer and Inter-Observer Variability

Jyotsna MaramDoheny Image Reading Center, Doheny Eye Institute, Los Angeles, CA, USA,

Xiaojing PanDoheny Image Reading Center, Doheny Eye Institute, Los Angeles, CA, USA, ;The Affiliated Hospital of Medical College, Qingdao University, Shandong, P.R. China, and

Srinivas SaddaDoheny Image Reading Center, Doheny Eye Institute, Los Angeles, CA, USA, ;Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA

Brian FrancisDoheny Image Reading Center, Doheny Eye Institute, Los Angeles, CA, USA, ;Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA

Kenneth MarionDoheny Image Reading Center, Doheny Eye Institute, Los Angeles, CA, USA,

Vikas ChopraDoheny Image Reading Center, Doheny Eye Institute, Los Angeles, CA, USA, ;Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USACorrespondence[email protected]

Abstract

Purpose: To evaluate the reproducibility of anterior chamber angle measurements obtained by the Zeiss Visante anterior segment optical coherence tomography (AS-OCT).

Methods: Twenty eyes from 20 normal subjects with open anterior chamber angles were studied. The anterior chamber angle was imaged using the Visante AS-OCT. The angle-opening distance (AOD 500, AOD 750), trabercular iris space area (TISA 500, TISA 750) and scleral spur angle (SS angle) at the inferior angle location were measured. All the subjects underwent imaging in a darkened room (1 foot candles measured at the eye). Images were graded in a masked fashion by certified Doheny Image Reading Center graders. For intra-grader reproducibility assessments, images were re-graded by the same grader 1 week later after random sorting of images. For inter-grader assessments, a second masked grader independently reviewed the images. Intraclass correlation coefficients (ICC) were used to assess reproducibility.

Results: Inferior angle measurements of AOD (500, 750), TISA (500, 750) and SS angle for 20 normal eyes were calculated. The intra-observer ICC calculations showed excellent reproducibility for all measurements (AOD 500 = 0.95, AOD 750 = 0.97, TISA 500 = 0.93, TISA 750 = 0.94, SS = 0.96; p < 0.001 for all). The inter-observer ICC calculations showed lower reproducibility for all measurements (AOD 500 = 0.71, p < 0.001; AOD 750 = 0.82, p < 0.001; TISA 500 = 0.49, p = 0.08; TISA 750 = 0.61, p = 0.02; SS = 0.75).

Conclusion: Determination of anterior chamber angle measurements was possible with the time-domain AS-OCT, but only modest inter-observer reproducibility was found even among experienced graders.

Keywords

DECLARATION OF INTEREST

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the article.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Reproducibility of Angle Metrics Using the Time-Domain Anterior Segment Optical Coherence Tomography: Intra-Observer and Inter-Observer Variability

Information for

Open access

Opportunities

Help and information

Reproducibility of Angle Metrics Using the Time-Domain Anterior Segment Optical Coherence Tomography: Intra-Observer and Inter-Observer Variability

Abstract

DECLARATION OF INTEREST

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature