PTGFR and SLCO2A1 Gene Polymorphisms Determine Intraocular Pressure Response to Latanoprost in Han Chinese Patients with Glaucoma

ABSTRACT

Purpose: To determine the relationship between the polymorphisms of the prostaglandin F2α receptor (PTGFR) and solute carrier organic anion transporter family 2A1 (SLCO2A1) genes and response to latanoprost treatment in Han Chinese patients with glaucoma.

Materials and Methods: 89 patients with POAG or OH received latanoprost treatment and intraocular pressure (IOP) data was collected on day 7 and day 30. The rs12093097, rs35586449, rs3753380, and rs3766355 single-nucleotide polymorphisms (SNPs) in the PTGFR gene and rs2370512, rs34550074, and rs4241366 SNPs in the SLCO2A1 gene were analyzed using direct DNA sequencing or polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP).

Results: The IOP in patients with GG allele of rs4241366 was lower than in patients with GC+CC on day 7 (p = 0.007). The IOP in patients with CC allele of rs3766355 was lower than in patients with CA+AA on day 30 (p = 0.024). Multiple regression analysis demonstrated that even after adjusting for baseline IOP, the rs4241366 in SLCO2A1 gene and the rs3766355 in PTGFR gene correlated with response to latanoprost on day 7 (rs4241366, p = 0.014) and day 30 (rs3766355, p = 0.035), respectively, in Han Chinese patients with glaucoma.

Conclusions: An association was found between single nucleotide polymorphisms of the PTGFR and SLCO2A1 genes and the response to latanoprost in Han Chinese patients with glaucoma. These SNPs may be important determinants of differential response to latanoprost.

Keywords:

• Glaucoma
• intraocular pressure
• latanoprost
• ocular hypertension
• pharmacogenetics

Acknowledgments

We thank Pharmacogenetics Research Institute of Clinical Pharmacology of Central South University and Metabolic Syndrome Research Center of Central South University which provided gene detection sites for this research.

Declaration of interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.

Funding

This research was supported by the National Natural Science Foundation of China (grant numbers NSFC 81271004, NSFC 81371012, to Bing Jiang); Department of Science and Technology, Hunan Province (grant number 2013TZ2013, to Bing Jiang); and Development and Reform Commission of Hunan Province (grant number 2014-658, to Bing Jiang).

Additional information

Funding

This research was supported by the National Natural Science Foundation of China (grant numbers NSFC 81271004, NSFC 81371012, to Bing Jiang); Department of Science and Technology, Hunan Province (grant number 2013TZ2013, to Bing Jiang); and Development and Reform Commission of Hunan Province (grant number 2014-658, to Bing Jiang).