FAD-induced in vitro activation of glutathione reductase in the lens of B₂ deficient rats

Abstract

We studied the FAD-induced in vitro stimulation of lenticular glutathione reductase in riboflavin-deficient rats. The stimulatory effect of FAD on lenticular glutathione reductase in rats fed a B₂-deficient diet for 4 weeks was remarkably higher than in paired control rats fed a B₂-supplemented basal diet and control rats had ad libitum access to a B₂-supplemented basal diet. The in vitro FAD stimulation effect on rat lenticular glutathione reductase represents a sensitive indicator of the B₂ deficient status.