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Current Eye Research Volume 3, 1984 - Issue 4
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Original Article

Decrease of intracellular chloride activity by furosemide in frog retinal pigment epithelium

Michael Wiederholt Inst. Klin. Physiol., Klinikum Steglitz, Freie Univ. Berlin, 1000, Berlin 45, FRG; Mount Desert Island Biol. Lab., Salsbury Cove, ME, 04672, USA
&
Jose A. Zadunaisky Dep. Physiol. and Ophthalmol., New York Univ. Med. Cent., New York, NY, 10016; Mount Desert Island Biol. Lab., Salsbury Cove, ME, 04672, USA
Pages 673-675 | Received 17 Nov 1983, Accepted 17 Jan 1984, Published online: 02 Jul 2009
 
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Abstract

We found that intracellular chloride activity in frog retinal pigment epithelium (RPE) was significantly higher than predicted from the equilibrium distribution across the cell membranes. When transepithelial chloride transport was inhibited by furosemide intracellular chloride activity decreased and approached electrochemical equilibrium. These data indicate that RPE possesses an active, furosemide-sensitive chloride transport across the apical membrane.

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