Nucleotide Sequence for the cDNA of the Bovine βB2 Crystallin and Assignment of the Orthologous Human Locus to Chromosome 22

David Hogg Mount Sinai Research Institute, Toronto, Ontario, Canada

Michael B. Gorin Jules Stein Eye Institute, Los Angeles, CA

Camilla Heinzmann Department of Medicine, UCLA Center for Health Sciences, Los Angeles, CA, USA

Susan Zollman Department of Medicine, UCLA Center for Health Sciences, Los Angeles, CA, USA

T. Mohandas Division of Medical Genetics, Harbor-UCLA Medical Center, Torrance, CA, USA

Ivana Klisak Department of Medicine, UCLA Center for Health Sciences, Los Angeles, CA, USA

Robert S. Sparkes Department of Medicine, UCLA Center for Health Sciences, Los Angeles, CA, USA

Martin Breitman Mount Sinai Research Institute, Toronto, Ontario, Canada

Lap-Chee Tsui Hospital for Sick Children, Toronto, Ontario, Canada

Joseph Horwitz Jules Stein Eye Institute, Los Angeles, CA

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Abstract

We have identified and characterized two overlapping bovine cDNA clones corresponding to the bovine crystallin βBp. The longer of the two clones, which contains the entire coding and 3′ untranslated region as well as 54 nucleotides of the 5′ untranslated sequence was used to identify and map an orthologous human gene, HuβB2, to chromosome 22, q11.2-q12.2. As one other human p-crystallin, HuβA3/A1, has been mapped to chromosome 17, our results indicate that, unlike the tightly linked γ-crystallins, the human β-crystallins are not syntenic within the genome.

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Nucleotide Sequence for the cDNA of the Bovine βB2 Crystallin and Assignment of the Orthologous Human Locus to Chromosome 22

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Nucleotide Sequence for the cDNA of the Bovine βB2 Crystallin and Assignment of the Orthologous Human Locus to Chromosome 22

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