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Current Eye Research Volume 6, 1987 - Issue 6
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Original Article

Heterogeneous expression of melanoma-associated antigens in uveal melanomas

J. P. van der Pol Departments of Pathology, University Medical Centre, Amsterdam, The Netherlands; Departments of Ophthalmology, University Medical Centre, Leiden, Amsterdam, The Netherlands; Department of Ophthalmo-Immunology, The Netherlands Ophthalmic Research Institute, Amsterdam
,
M. J. Jager Department of Ophthalmology, Academical Medical Centre, Amsterdam, The Netherlands
,
D. de Wolff-Rouendaal Departments of Ophthalmology, University Medical Centre, Leiden, Amsterdam, The Netherlands
,
P. J. Ringens Department of Ophthalmology, University Medical Centre, Rotterdam, The Netherlands
,
C. Vennegoor Department of Immunology, Netherlands Cancer Institute, Amsterdam, The Netherlands
&
D. J. Ruiter Departments of Pathology, University Medical Centre, Amsterdam, The Netherlands; Department of Pathology, University of Nijmegen, Nijmegen, The Netherlands
Pages 757-765 | Received 29 Dec 1986, Accepted 23 Apr 1987, Published online: 02 Jul 2009
 
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Abstract

Twenty-five uveal melanomas were stained with seven monoclonal antibodies (MoAbs) recognizing different antigens on cutaneous melanomas. A two step immuno-peroxidase procedure was used. Phenotypic heterogeneity was observed for four MoAbs (M.2.2.4, AMF-7, 225.28S, PAL-M1) while two MoAbs (NKI-beteb, CL203.4) reacted strongly with most (85%) uveal melanomas, and one MoAb (R-24) showed very low reactivity. Despite heterogeneity, co-expression of some antigens was observed. Expression of the antigen recognized by MoAb M.2.2.4. was significantly lowered by pre-enucleation irradiation while the other antigens remained unchanged. Expression of antigens on uveal melanomas differed markedly from primary cutaneous melanomas. The clinical relevance of these findings awaits further study.

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