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Current Eye Research Volume 9, 1990 - Issue 4
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Original Article

Expression of IGF-I and IGF-II genes in the adult rat eye

John Danias Laboratory of Histology and Embryology, School of Health Sciences, University of Athens, Athens, Greece
&
Fotini Stylianopoulou Laboratory of Histology and Embryology, School of Health Sciences, University of Athens, Athens, Greece
Pages 379-386 | Received 01 Nov 1989, Accepted 14 Mar 1990, Published online: 02 Jul 2009
 
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Abstract

We have investigated the transcription of IGF-I and IGF-II genes in the adult rat eye. Each eye was dissected into cornea, lens, sclera+choroid+pigment epithelium, and neural retina. Total cellular RNA was isolated from each of these tissues. Northern blot analysis using rat coding region cDNA probes revealed the presence of IGF-I and IGF-II specific transcripts in the retina and the sclera but not in the lens and cornea. Retina demonstrated the highest level of IGF-I and IGF-II expression. Our results suggest autocrine and paracrine effects of the IGFs and their possible involvement in normal eye physiology as well as in the pathogenesis of certain eye diseases.

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