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Current Eye Research Volume 10, 1991 - Issue 10
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Original Article

Histochemical localization of superoxide production in experimental autoimmune uveitis

David C. Gritz Doheny Eye Institute and Department of Ophthalmology, University of Southern California School of Medicine, Los Angeles, California, USA
,
Carolina Montes Doheny Eye Institute and Department of Ophthalmology, University of Southern California School of Medicine, Los Angeles, California, USA
,
Lily R. Atalla Doheny Eye Institute and Department of Ophthalmology, University of Southern California School of Medicine, Los Angeles, California, USA
,
Guey-Shuang Wu Doheny Eye Institute and Department of Ophthalmology, University of Southern California School of Medicine, Los Angeles, California, USA
,
Alex Sevanian Institute for Toxicology and Department of Pathology, University of Southern California School of Medicine, Los Angeles, California, USA
&
Narsing A. Rao Doheny Eye Institute and Department of Ophthalmology, University of Southern California School of Medicine, Los Angeles, California, USA
Pages 927-931 | Received 05 Apr 1991, Accepted 26 Aug 1991, Published online: 02 Jul 2009
 
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Abstract

Although the presence and role of oxygen reactive species in uveal inflammation is the subject of intense investigation, there is little direct evidence that oxygen metabolites are present at the site of inflammation. We used the nitroblue tetrazolium test for superoxide to determine production of this oxygen reactive species in experimental autoimmune uveitis (EAU). The choroidal tissues of animals with this disease contained intracellular, blue-staining granules. Most of the positive staining cells appeared to be polymorphonuclear leukocytes. This localization of superoxide in EAU is further evidence of the generation of oxygen reactive species in uveal inflammation.

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