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Current Eye Research Volume 12, 1993 - Issue 10
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Original Article

Age-related changes in the molecular properties of vitreous collagen

Jun Akiba Department of Ophthalmology, Harvard Medical School, Schepens Eye Research Institute, Boston, MA, USA; Department of Ophthalmology, Asahikawa Medical College, Asahikawa, Japan
,
Norio Ueno Department of Ophthalmology, Harvard Medical School, Schepens Eye Research Institute, Boston, MA, USA
&
Bireswar Chakrabarti Department of Ophthalmology, Harvard Medical School, Schepens Eye Research Institute, Boston, MA, USA
Pages 951-954 | Received 31 Mar 1993, Accepted 01 Oct 1993, Published online: 02 Jul 2009
 
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Abstract

To understand the molecular events underlying rheological vitreous changes, age-related changes in the molecular properties of bovine and human vitreous collagen were monitored by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The adult bovine vitreous showed an increase in the highmolecular-weight components of the collagen compared with the young samples. In addition, the apparent molecular size of the α-chain of the adult type II collagen was slightly larger than that of the young samples. The same tendency also was observed in human vitreous. The increase of high-molecular-weight components of the vitreous collagen could be attributed to intermolecular cross-links of the peptide chains.

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