jun-B gene expression in rat retinal cells following focal retinal injury

Kazutaka Ohki Department of Ophthalmology, Hokkaido University School of Medicine, N15 W7, Kita-ku, Sapporo 060

Kazuhiko Yoshida Department of Ophthalmology, Hokkaido University School of Medicine, N15 W7, Kita-ku, Sapporo 060

Akio Yamakawa Department of Ophthalmology, Hokkaido University School of Medicine, N15 W7, Kita-ku, Sapporo 060; Department of Biosignal Research, Tokyo Metropolitan Institute of Gerontology, 35-2, Sakaecho, Itabashi-ku, Tokyo, 173

Takayuki Harada Department of Ophthalmology, Hokkaido University School of Medicine, N15 W7, Kita-ku, Sapporo 060

Hidehiko Matsuda Department of Ophthalmology, Hokkaido University School of Medicine, N15 W7, Kita-ku, Sapporo 060

Junko Imaki Department of Ophthalmology, Hokkaido University School of Medicine, N15 W7, Kita-ku, Sapporo 060; Department of Anatomy, Nippon Medical School, 1-1-5, Sendagi, Bunkyo-ku, Tokyo, 113, Japan

Abstract

We examined jun-B gene expression in the rat retina after a focal retinal injury by in situ hybridization. 30 min after producing a penetrating retinal wound, the retina showed the expression of jun-B mRNA intensively in the inner nuclear layer (INL) and relatively sparsely in the ganglion cell layer. The double-labeled retina by immunocytochemistry and in situ hybridization demonstrated that jun-B mRNA within the INL surrounded S-100 protein immunoreactive cytoplasm in the middle sublayer of the INL. These results suggest that the jun-B expression is induced mainly in Müller cells following retinal damage.

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jun-B gene expression in rat retinal cells following focal retinal injury

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jun-B gene expression in rat retinal cells following focal retinal injury

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