Reversal of Adrenal Suppression with Ciclesonide

Abstract

Background. Adrenal suppression secondary to high-dose inhaled corticosteroid use has been reported in children. Methods. The authors report the use of ciclesonide to reverse adrenal suppression secondary to inhaled fluticasone use in four pediatric patients. Results. In these four children, hypothalamic-pituitary-adrenal axis function normalized after the patients were changed to ciclesonide, while good asthma control was maintained. Conclusions. Ciclesonide should be considered for the reversal of adrenal suppression secondary to the use of fluticasone, and perhaps other older inhaled corticosteroids as well.

Keywords :

• adrenal insufficiency
• child and adolescent
• ciclesonide
• fluticasone
• glucocorticoids