Comparison of Nifedipine with a New Calcium Channel Blocker, Flordipine, in Exercise-Induced Asthma

Eve H. Gordon Allergy and Immunology Section Departments of Medicine and Research Wadsworth VA Medical Center and UCLA School of Medicine, Los Angeles, California

Stephen C. Wong Allergy and Immunology Section Departments of Medicine and Research Wadsworth VA Medical Center and UCLA School of Medicine, Los Angeles, California

William B. Klaustermeyer Allergy and Immunology Section Departments of Medicine and Research Wadsworth VA Medical Center and UCLA School of Medicine, Los Angeles, California

Abstract

Four patients with documented exercise-induced asthma (EIA) were pretreated orally in random, double-blind fashion with the calcium channel blockers nifedipine 20 mg and flordipine 25 and 50 mg and placebo, then subjected to exercise challenge on a cycloergometer. Each patient served as his own control, undergoing exercise challenge with the different pretreatments on 4 separate days. No statistically significant protection from EIA was found with either nifedipine or flordipine.

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Comparison of Nifedipine with a New Calcium Channel Blocker, Flordipine, in Exercise-Induced Asthma

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Comparison of Nifedipine with a New Calcium Channel Blocker, Flordipine, in Exercise-Induced Asthma

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