Effect of Combined H-1 and H-2 Histamine Receptor Antagonists on Late Asthmatic Response in an Asthmatic Patient

Abstract

A curious inhibitory effect of histamine H-1 and H-2 antagonists on isolated late asthmatic response (LAR) in an asthmatic patient was observed.

When given alone, neither the H-1 nor the H-2 antagonist had an effect on LAR. The combination of drugs, however, provided marked inhibition of LAR. These findings suggest that histamine contributes to some types of LAR.