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Abstract
Corticotropin-releasing hormone (CRH) exhibits anti-inflammatory properties independent of its effect on adrenal function. We investigated the safety and effect of CRH in nocturnal asthma, a disease where inflammation is prominent. Five subjects underwent an overnight infusion of placebo on the first night, CRH at a 2.5 μg/kg/hr on the second night, and three subjects received CRH at 4.0 μg/kg/hr on the third night. A significant improvement occurred in overnight change in forced expiratory volume at 1 sec. % (δFEV1) with CRH (+17.4 ± 9.1 %) as opposed to placebo (−25.9 ± 7.1%), p = 0.024. CRH was well tolerated. Further research with CRH may clarify the pathophysiology of nocturnal asthma.