Immunodeficiency and Prognosis in Patients with Non-Hodgkin's Lymphomas

C. Lindemalm RADIUMHEMMET AND THE DEPARTMENTS OF RADIATION BIOLOGY, PATHOLOGY AND CANCER EPIDEMIOLOGY, KAROLINSKA SJUKHUSET, S-10401, STOCKHOLM; THE DEPARTMENT OF MEDICINE, DANDERYDS SJUKHUS, S-182 88, DANDERYD; THE DEPARTMENT OF CLINICAL IMMUNOLOGY, HUDDINGE SJUKHUS, S-141 86, HUDDINGE, SWEDEN

P. Biberfeld RADIUMHEMMET AND THE DEPARTMENTS OF RADIATION BIOLOGY, PATHOLOGY AND CANCER EPIDEMIOLOGY, KAROLINSKA SJUKHUSET, S-10401, STOCKHOLM; THE DEPARTMENT OF MEDICINE, DANDERYDS SJUKHUS, S-182 88, DANDERYD; THE DEPARTMENT OF CLINICAL IMMUNOLOGY, HUDDINGE SJUKHUS, S-141 86, HUDDINGE, SWEDEN

M. Björkholm RADIUMHEMMET AND THE DEPARTMENTS OF RADIATION BIOLOGY, PATHOLOGY AND CANCER EPIDEMIOLOGY, KAROLINSKA SJUKHUSET, S-10401, STOCKHOLM; THE DEPARTMENT OF MEDICINE, DANDERYDS SJUKHUS, S-182 88, DANDERYD; THE DEPARTMENT OF CLINICAL IMMUNOLOGY, HUDDINGE SJUKHUS, S-141 86, HUDDINGE, SWEDEN

G. Holm RADIUMHEMMET AND THE DEPARTMENTS OF RADIATION BIOLOGY, PATHOLOGY AND CANCER EPIDEMIOLOGY, KAROLINSKA SJUKHUSET, S-10401, STOCKHOLM; THE DEPARTMENT OF MEDICINE, DANDERYDS SJUKHUS, S-182 88, DANDERYD; THE DEPARTMENT OF CLINICAL IMMUNOLOGY, HUDDINGE SJUKHUS, S-141 86, HUDDINGE, SWEDEN

B. Johansson RADIUMHEMMET AND THE DEPARTMENTS OF RADIATION BIOLOGY, PATHOLOGY AND CANCER EPIDEMIOLOGY, KAROLINSKA SJUKHUSET, S-10401, STOCKHOLM; THE DEPARTMENT OF MEDICINE, DANDERYDS SJUKHUS, S-182 88, DANDERYD; THE DEPARTMENT OF CLINICAL IMMUNOLOGY, HUDDINGE SJUKHUS, S-141 86, HUDDINGE, SWEDEN

H. Mellstedt RADIUMHEMMET AND THE DEPARTMENTS OF RADIATION BIOLOGY, PATHOLOGY AND CANCER EPIDEMIOLOGY, KAROLINSKA SJUKHUSET, S-10401, STOCKHOLM; THE DEPARTMENT OF MEDICINE, DANDERYDS SJUKHUS, S-182 88, DANDERYD; THE DEPARTMENT OF CLINICAL IMMUNOLOGY, HUDDINGE SJUKHUS, S-141 86, HUDDINGE, SWEDEN

B. Nilsson RADIUMHEMMET AND THE DEPARTMENTS OF RADIATION BIOLOGY, PATHOLOGY AND CANCER EPIDEMIOLOGY, KAROLINSKA SJUKHUSET, S-10401, STOCKHOLM; THE DEPARTMENT OF MEDICINE, DANDERYDS SJUKHUS, S-182 88, DANDERYD; THE DEPARTMENT OF CLINICAL IMMUNOLOGY, HUDDINGE SJUKHUS, S-141 86, HUDDINGE, SWEDEN

å. öst RADIUMHEMMET AND THE DEPARTMENTS OF RADIATION BIOLOGY, PATHOLOGY AND CANCER EPIDEMIOLOGY, KAROLINSKA SJUKHUSET, S-10401, STOCKHOLM; THE DEPARTMENT OF MEDICINE, DANDERYDS SJUKHUS, S-182 88, DANDERYD; THE DEPARTMENT OF CLINICAL IMMUNOLOGY, HUDDINGE SJUKHUS, S-141 86, HUDDINGE, SWEDEN

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Abstract

Monocyte depleted blood lymphocyte subpopulations, their functions and relation to prognosis were studied in 68 untreated adult patients with non-Hodgkin's lympho-mas classified according to the Kiel nomenclature. The median observation time was 48 months (range 41–60). The mean total blood lymphocyte and T (SRBC-rosetting) cell counts were signiticantly decreased as compared with age-matched controls (n=57). Twenty-five per cent of the patients had a monoclonal blood B lymphocyte population. The spontaneous lymphocyte DNA synthesis, measured as incorporation of ¹⁴C-thymidine, was increased and the response to mitogen and antigen stimulation was decreased. Blood lymphocyte counts and functions before treatment were not related to the rates of remission or survival.

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Immunodeficiency and Prognosis in Patients with Non-Hodgkin's Lymphomas

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Immunodeficiency and Prognosis in Patients with Non-Hodgkin's Lymphomas

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