Different Fractionation Schedules in Radiation Treatment of Cerebral Metastases

F. D'elia Department of Pathophysiology, Radiology Institute, University of Florence and the Radiology Institute, University of Siena, Italy

I. Bonucci Department of Pathophysiology, Radiology Institute, University of Florence and the Radiology Institute, University of Siena, Italy

G. P. Biti Department of Pathophysiology, Radiology Institute, University of Florence and the Radiology Institute, University of Siena, Italy

L. Pirtoli Department of Pathophysiology, Radiology Institute, University of Florence and the Radiology Institute, University of Siena, Italy

Abstract

Multiple daily fractionation (MDF) was compared, in a cooperative study, with conventional fractionation (CF) in the radiation treatment of brain metastases. The 103 patients treated by MDF and the 44 given CF showed a similar response, in terms of neurologic improvement, survival, quality of residual life, and treatment-related morbidity. The hypothesis that MDF might give a better therapeutic ratio than CF was not confirmed in the present series. The short time period required gives MDF advantages in clinical practice.

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Different Fractionation Schedules in Radiation Treatment of Cerebral Metastases

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Different Fractionation Schedules in Radiation Treatment of Cerebral Metastases

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