Late Radiation Enteropathy Following Split-Dose Irradiation of Rat Small Intestine

M. Hauer Jensen Departments of Surgery and Pathology, Ulleval University Hospital, Oslo, Norway; The Experimental Animal Department, The National Hospital, University of Oslo, and the National Institute of Radiation Hygiene, Oslo, Norway

T. Sauer Departments of Surgery and Pathology, Ulleval University Hospital, Oslo, Norway; The Experimental Animal Department, The National Hospital, University of Oslo, and the National Institute of Radiation Hygiene, Oslo, Norway

J. B. Reitan Departments of Surgery and Pathology, Ulleval University Hospital, Oslo, Norway; The Experimental Animal Department, The National Hospital, University of Oslo, and the National Institute of Radiation Hygiene, Oslo, Norway

K. Nygaard Departments of Surgery and Pathology, Ulleval University Hospital, Oslo, Norway; The Experimental Animal Department, The National Hospital, University of Oslo, and the National Institute of Radiation Hygiene, Oslo, Norway

Abstract

In female Wistar rats roentgen irradiation of a 10 cm long exteriorized mid small intestinal segment was performed. The radiation dose was 23 Gy, given as a single exposure or divided in two equal fractions separated by intervals of 4 to 96 hours. Radiation injury was assessed 2, 8 and 26 weeks following irradiation using a semiquantitative histopathologic scoring system. An increased fractionation interval led to a reduced degree of radiation injury at all 3 observation times. The greatest difference was found between the single dose and 4 hour groups, indicating a relatively large capacity for repair of sublethal damage. The degree of radiation injury also decreased significantly when the interval between fractions was increased from 4 hours to 96 hours. This suggests that the phenomenon of slow repair may occur in cells involved in the development of late radiation enteropathy. However, an indirectly protective effect due to mucosal repopulation between fractions may also explain some of the differences.

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Late Radiation Enteropathy Following Split-Dose Irradiation of Rat Small Intestine

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Late Radiation Enteropathy Following Split-Dose Irradiation of Rat Small Intestine

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