Treatment of Lung Cancer with Bronchial Artery Infusion of Cisplatin and Intravenous Sodium Thiosulfate Rescue

Abstract

Forty-nine patients with primary lung cancer were treated with bronchial artery infusion of cisplatin and intravenous injection of an antidote, sodium thiosulfate. More than 50% reduction of tumor size (PR) was observed in 8 of 9 small cell carcinomas (SCLC) and in 16 of 40 non-small cell carcinomas (NSCLC). In NSCLC patients PR was obtained in 71% (12/17) after repeated infusions (200 mg cisplatin) and in 17% (4/23) after a single infusion (150 mg cisplatin). There was a significant linear relationship between cisplatin dose and tumor reduction in this group. No severe adverse effects were encountered.

Key Words:

• Chemotherapy
• intra-arterial
• lung cancer
• cisplatin
• bronchial artery infusion
• sodium thiosulfate rescue