Additional information from Quantitative 24-Hour ^99MTc-Mdp Bone Scintigraphy in Patients with Prostatic Carcinoma

Abstract

Quantitative bone scintigraphy was performed at 4 and 24 h after injection of ^99mTc-MDP. the lower thoracic and all the lumbar vertebrae were recorded in 37 patients with prostatic carcinoma before orchiectomy as well as two weeks, two and six months postoperatively. Fourteen patients had normal bone scintigrams. By means of the measured variation in the count rate between normal vertebrae, the criterion for a vertebra to be considered as abnormal was determined using the 4h-uptake values. for patients with normal scintigrams the count rate at 24 h was below the 4h level and the mean 24h/4h ratio was determined to be 0.85 ± 0.09 (1 SD). Normal vertebrae in patients with skeletal metastases had only slightly lower count rate values at 24 h than at 4 h. Abnormal vertebrae showed a higher count rate at 24 h, especially two weeks postoperatively, while a tendency towards lower values than at 4 h was seen after 6 months. If the 24 h/4 h ratio is used as an extra criterion to the count rate at 4 h, the vertebrae will be more accurately defined as normal or abnormal.

Key Words:

• Prostatic carcinoma
• skeletal metastases
• quantitative bone scintigraphy