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Acta Oncologica Volume 31, 1992 - Issue 1
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Original Article

Effect of Recombinant Human Granulocyte Colony-Stimulating Factor on Survival in Lethally Irradiated Mice

Y. Hosor Departments of Radiation Research and Radiology, Tohoku University School of Medicine, Sendai, Japan
,
A. Kurishita Departments of Radiation Research and Radiology, Tohoku University School of Medicine, Sendai, Japan
,
T. Ono Departments of Radiation Research and Radiology, Tohoku University School of Medicine, Sendai, Japan
&
K. Sakamoto Departments of Radiation Research and Radiology, Tohoku University School of Medicine, Sendai, Japan
Pages 59-63 | Accepted 21 Sep 1991, Published online: 08 Jul 2009
 
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Abstract

Repeated injections of recombinant human granulocyte colony-stimulating factor (rhC-CSF) to lethally irradiated mice increased the rate of animal survival. Dose modification factor was 1.20 when 4.5 μg/mouse of rhC-CSF was given daily for 14 days after whole body irradiation. Haematological examinations revealed that rhC-CSF increased the number of bloodcirculating leukocytes, neutrophils, monocytes and erythrocytes, but not that of lymphocytes and thrombocytes. Spleen weight and number of endogenous spleen colonies were also increased by rhC-CSF treatment compared with the values for mice irradiated only.

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