Inherited Breast Carcinoma: Prospective findings in 1 194 women at risk

Pål Møller Unit of Medical Genetics, Department of Oncology, Surgical Department, Department of Radiology, Department of Pathology, Department of Gynecology, The Norwegian Radium Hospital, Oslo; The Cancer Registry of Norway, Oslo; Surgical Department, Ullevål Hospital, Oslo; Surgical Department, Rogaland Central Hospital, Stavanger; Surgical Department, Haukeland University Hospital, Bergen; Surgical Department, The Regional Hospital, Trondheim; Surgical Department, Nordland Central Hospital, Bodø

Lovise Maehle Unit of Medical Genetics, Department of Oncology, Surgical Department, Department of Radiology, Department of Pathology, Department of Gynecology, The Norwegian Radium Hospital, Oslo; The Cancer Registry of Norway, Oslo; Surgical Department, Ullevål Hospital, Oslo; Surgical Department, Rogaland Central Hospital, Stavanger; Surgical Department, Haukeland University Hospital, Bergen; Surgical Department, The Regional Hospital, Trondheim; Surgical Department, Nordland Central Hospital, Bodø

Ketil Heimdal Unit of Medical Genetics, Department of Oncology, Surgical Department, Department of Radiology, Department of Pathology, Department of Gynecology, The Norwegian Radium Hospital, Oslo; The Cancer Registry of Norway, Oslo; Surgical Department, Ullevål Hospital, Oslo; Surgical Department, Rogaland Central Hospital, Stavanger; Surgical Department, Haukeland University Hospital, Bergen; Surgical Department, The Regional Hospital, Trondheim; Surgical Department, Nordland Central Hospital, Bodø

Anne Dørum Unit of Medical Genetics, Department of Oncology, Surgical Department, Department of Radiology, Department of Pathology, Department of Gynecology, The Norwegian Radium Hospital, Oslo; The Cancer Registry of Norway, Oslo; Surgical Department, Ullevål Hospital, Oslo; Surgical Department, Rogaland Central Hospital, Stavanger; Surgical Department, Haukeland University Hospital, Bergen; Surgical Department, The Regional Hospital, Trondheim; Surgical Department, Nordland Central Hospital, Bodø

Steinar Tretli Unit of Medical Genetics, Department of Oncology, Surgical Department, Department of Radiology, Department of Pathology, Department of Gynecology, The Norwegian Radium Hospital, Oslo; The Cancer Registry of Norway, Oslo; Surgical Department, Ullevål Hospital, Oslo; Surgical Department, Rogaland Central Hospital, Stavanger; Surgical Department, Haukeland University Hospital, Bergen; Surgical Department, The Regional Hospital, Trondheim; Surgical Department, Nordland Central Hospital, Bodø

Per Helgerud Unit of Medical Genetics, Department of Oncology, Surgical Department, Department of Radiology, Department of Pathology, Department of Gynecology, The Norwegian Radium Hospital, Oslo; The Cancer Registry of Norway, Oslo; Surgical Department, Ullevål Hospital, Oslo; Surgical Department, Rogaland Central Hospital, Stavanger; Surgical Department, Haukeland University Hospital, Bergen; Surgical Department, The Regional Hospital, Trondheim; Surgical Department, Nordland Central Hospital, Bodø

Hanne Quist Unit of Medical Genetics, Department of Oncology, Surgical Department, Department of Radiology, Department of Pathology, Department of Gynecology, The Norwegian Radium Hospital, Oslo; The Cancer Registry of Norway, Oslo; Surgical Department, Ullevål Hospital, Oslo; Surgical Department, Rogaland Central Hospital, Stavanger; Surgical Department, Haukeland University Hospital, Bergen; Surgical Department, The Regional Hospital, Trondheim; Surgical Department, Nordland Central Hospital, Bodø

Hilde Bjørndal Unit of Medical Genetics, Department of Oncology, Surgical Department, Department of Radiology, Department of Pathology, Department of Gynecology, The Norwegian Radium Hospital, Oslo; The Cancer Registry of Norway, Oslo; Surgical Department, Ullevål Hospital, Oslo; Surgical Department, Rogaland Central Hospital, Stavanger; Surgical Department, Haukeland University Hospital, Bergen; Surgical Department, The Regional Hospital, Trondheim; Surgical Department, Nordland Central Hospital, Bodø

Rolf Kåresen Unit of Medical Genetics, Department of Oncology, Surgical Department, Department of Radiology, Department of Pathology, Department of Gynecology, The Norwegian Radium Hospital, Oslo; The Cancer Registry of Norway, Oslo; Surgical Department, Ullevål Hospital, Oslo; Surgical Department, Rogaland Central Hospital, Stavanger; Surgical Department, Haukeland University Hospital, Bergen; Surgical Department, The Regional Hospital, Trondheim; Surgical Department, Nordland Central Hospital, Bodø

Arne Nysted Unit of Medical Genetics, Department of Oncology, Surgical Department, Department of Radiology, Department of Pathology, Department of Gynecology, The Norwegian Radium Hospital, Oslo; The Cancer Registry of Norway, Oslo; Surgical Department, Ullevål Hospital, Oslo; Surgical Department, Rogaland Central Hospital, Stavanger; Surgical Department, Haukeland University Hospital, Bergen; Surgical Department, The Regional Hospital, Trondheim; Surgical Department, Nordland Central Hospital, Bodø

Jan E. Varhaug Unit of Medical Genetics, Department of Oncology, Surgical Department, Department of Radiology, Department of Pathology, Department of Gynecology, The Norwegian Radium Hospital, Oslo; The Cancer Registry of Norway, Oslo; Surgical Department, Ullevål Hospital, Oslo; Surgical Department, Rogaland Central Hospital, Stavanger; Surgical Department, Haukeland University Hospital, Bergen; Surgical Department, The Regional Hospital, Trondheim; Surgical Department, Nordland Central Hospital, Bodø

Hans E. Fjøsne Unit of Medical Genetics, Department of Oncology, Surgical Department, Department of Radiology, Department of Pathology, Department of Gynecology, The Norwegian Radium Hospital, Oslo; The Cancer Registry of Norway, Oslo; Surgical Department, Ullevål Hospital, Oslo; Surgical Department, Rogaland Central Hospital, Stavanger; Surgical Department, Haukeland University Hospital, Bergen; Surgical Department, The Regional Hospital, Trondheim; Surgical Department, Nordland Central Hospital, Bodø

Roald J. Guleng Unit of Medical Genetics, Department of Oncology, Surgical Department, Department of Radiology, Department of Pathology, Department of Gynecology, The Norwegian Radium Hospital, Oslo; The Cancer Registry of Norway, Oslo; Surgical Department, Ullevål Hospital, Oslo; Surgical Department, Rogaland Central Hospital, Stavanger; Surgical Department, Haukeland University Hospital, Bergen; Surgical Department, The Regional Hospital, Trondheim; Surgical Department, Nordland Central Hospital, Bodø

Jan Due Unit of Medical Genetics, Department of Oncology, Surgical Department, Department of Radiology, Department of Pathology, Department of Gynecology, The Norwegian Radium Hospital, Oslo; The Cancer Registry of Norway, Oslo; Surgical Department, Ullevål Hospital, Oslo; Surgical Department, Rogaland Central Hospital, Stavanger; Surgical Department, Haukeland University Hospital, Bergen; Surgical Department, The Regional Hospital, Trondheim; Surgical Department, Nordland Central Hospital, Bodø

Per Bøhler Unit of Medical Genetics, Department of Oncology, Surgical Department, Department of Radiology, Department of Pathology, Department of Gynecology, The Norwegian Radium Hospital, Oslo; The Cancer Registry of Norway, Oslo; Surgical Department, Ullevål Hospital, Oslo; Surgical Department, Rogaland Central Hospital, Stavanger; Surgical Department, Haukeland University Hospital, Bergen; Surgical Department, The Regional Hospital, Trondheim; Surgical Department, Nordland Central Hospital, Bodø

Karl Erik Giercksky Unit of Medical Genetics, Department of Oncology, Surgical Department, Department of Radiology, Department of Pathology, Department of Gynecology, The Norwegian Radium Hospital, Oslo; The Cancer Registry of Norway, Oslo; Surgical Department, Ullevål Hospital, Oslo; Surgical Department, Rogaland Central Hospital, Stavanger; Surgical Department, Haukeland University Hospital, Bergen; Surgical Department, The Regional Hospital, Trondheim; Surgical Department, Nordland Central Hospital, Bodø

Claes Tropé; Unit of Medical Genetics, Department of Oncology, Surgical Department, Department of Radiology, Department of Pathology, Department of Gynecology, The Norwegian Radium Hospital, Oslo; The Cancer Registry of Norway, Oslo; Surgical Department, Ullevål Hospital, Oslo; Surgical Department, Rogaland Central Hospital, Stavanger; Surgical Department, Haukeland University Hospital, Bergen; Surgical Department, The Regional Hospital, Trondheim; Surgical Department, Nordland Central Hospital, Bodø

Stener Kvinnsland Unit of Medical Genetics, Department of Oncology, Surgical Department, Department of Radiology, Department of Pathology, Department of Gynecology, The Norwegian Radium Hospital, Oslo; The Cancer Registry of Norway, Oslo; Surgical Department, Ullevål Hospital, Oslo; Surgical Department, Rogaland Central Hospital, Stavanger; Surgical Department, Haukeland University Hospital, Bergen; Surgical Department, The Regional Hospital, Trondheim; Surgical Department, Nordland Central Hospital, Bodø

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Abstract

According to preset criteria, 1194 women at risk for inherited breast carcinoma were selected and subjected to examination. Six hundred and three women were examined once, 591 were followed for a mean of 1.8 years. Twenty infiltrating cancers (median age 49 years) and 16 precancers (median age 44 years) were found, demonstrating that breast carcinoma continued to occur in the selected families as expected under the hypothesis of dominant inheritance. At first round, 14 (1.2%) infiltrating carcinomas and a total of 22 (1.8%) cancers or precancers were found. Incidence rates of 0.58% pr. year for infiltrating cancers, and 1.04% pr. year for cancer or precancer were calculated. This confirms the tentative conclusions that were drawn in our previous report. These are the first prospective reports documenting how to delineate a high risk group for premenopausal breast cancer, and how to diagnose cancer at an early stage. All but two affected women had cancer without lymph node metastasis. Although a longer observation time is needed, we cautiously conclude that the results are in keeping with our aim of providing safety for those at risk. Clinical use of predictive genetic testing may be implemented within these families.

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Inherited Breast Carcinoma: Prospective findings in 1 194 women at risk

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