Auger-Electron Spectra of Radionuclides for Therapy and Diagnostics

Abstract

The present paper documents the calculation of radiation spectra and of radial dose distribution around a point source for 24 selected radionculides. The radionculides were ordered into three groups: Nuclides potentially useful for therapy by emission of Auger electrons: ⁵¹Cr, ⁶⁴Cu, ⁶⁷Ga, ⁷³Se, ⁷⁵Se, ⁷⁷Br ⁸⁰Br, ⁹⁴Tc, ^99mTc, ^114mIn, ¹¹⁵In, ¹²³I, ¹²⁴I, ¹²⁵I, ¹⁶⁷Tm, ^193mPt, and ^195mPt, nuclides potentially useful for therapy by α-particles with additional emission of Auger electrons: ²¹²Bi, ²¹¹At and ²⁵⁵Fm, and nuclides potentially useful for electron Auger-therapy with simultaneous PET diagnosis: ⁷³Se, ⁹⁴Tc and ¹²⁴I. The calculations imply strongly the development of labelled DNA-seeking compounds useful as carrier for the Auger- and Coster-Kronig electron-emitting radionuclides.