Serum Isozyme Variations in Clinical Burns: Alterations in Naphthylamidase and Alkaline Phosphatase

Abstract

Alterations in the serum isozyme patterns of naphthylamidase and alkaline phosphatase were studied in 33 patients with acute burn injuries. In 30 patients a marked increase in a particular naphthylamidase component was found. The alterations in this enzyme were correlated with an increase in the serum alkaline phosphatase. The changes in these enzymes appeared 4–5 days after the burn trauma and persisted for a period of at least 2–3 months. The results were interpreted as manifestations of liver disturbances following the burn injury.