Influence of Estrogen and Progesterone on Exudation, Inflammatory Cell Migration and Granulation Tissue Formation in Preformed Cavities

Abstract

The aim of the present investigation was to analyse the influence of estrogen and/or progesterone on exudation, inflammatory cell migration and granulation tissue formation in inflamed areas of oophorectomized rats. The hormones were given daily for up to five weeks. Two weeks after the beginning of the hormone treatment perforated cylinders of Teflon® were implanted subcutaneously in the back of each rat (Lundgren & Lindhe, 1973). The cylinders were removed 12 hours, 4, 7, 14 and 21 days after implantation, after which the amount of exudate and the number of inflammatory cells within the cylinder cavity were measured. The amount of formed granulation tissue was recorded from day 7 inclusive. Progesterone treatment increased, and estrogen treatment decreased the accumulation of exudate as well as the number of inflammatory cells during the early phase after implantation. In the estrogen-treated animals the number of inflammatory cells and the amount of granulation tissue were markedly decreased throughout the experimental period.