Xeroderma Pigmentosum-Biochemical and Therapeutic Aspects

L. Bartholdson Department of Plastic Surgery (Head: B. Johanson), The Department of Dermatology (Head: G. Swanbeck), and the Department of Clinical Chemistry (Head: S. Lindstedt), Sahlgrenska sjukhuset, Göteborg, Sweden

J. Lilja Department of Plastic Surgery (Head: B. Johanson), The Department of Dermatology (Head: G. Swanbeck), and the Department of Clinical Chemistry (Head: S. Lindstedt), Sahlgrenska sjukhuset, Göteborg, Sweden

H. Mobacken Department of Plastic Surgery (Head: B. Johanson), The Department of Dermatology (Head: G. Swanbeck), and the Department of Clinical Chemistry (Head: S. Lindstedt), Sahlgrenska sjukhuset, Göteborg, Sweden

J. Waldenström Department of Plastic Surgery (Head: B. Johanson), The Department of Dermatology (Head: G. Swanbeck), and the Department of Clinical Chemistry (Head: S. Lindstedt), Sahlgrenska sjukhuset, Göteborg, Sweden

Abstract

Four patients with Xeroderma pigmentosum are reported: 2 diagnosed following the development of multiple cutaneous tumours, and 2 at an earlier state. The repair synthesis of DNA after ultraviolet radiation was reduced in 3 and normal in 1 patient. Para-aminobenzoic acid (PABA) was used topically as sunscreen; for those intolerant to PABA, alternatives are given. 5-fluoro-uracil had satisfactory effect against actinic keratoses. Two patients had associated neurologic and mental abnormalities compatible with deSanctis-Cacchione syndrome, a Xeroderma pigmentosum variant.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Xeroderma Pigmentosum-Biochemical and Therapeutic Aspects

Information for

Open access

Opportunities

Help and information

Xeroderma Pigmentosum-Biochemical and Therapeutic Aspects

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature