Effect of Dipyridamole on the Survival of Experimental Critical Skin Flaps

C. Arnander From the Department of Pathology (Head: G. Moberger), the Department of Plastic Surgery (Head: B. Nylén)and the Department of Thoracic Medicine (Head: Å. Hanngren), Karolinska sjukhuset, Stockholm, Sweden

G. Jurell From the Department of Pathology (Head: G. Moberger), the Department of Plastic Surgery (Head: B. Nylén)and the Department of Thoracic Medicine (Head: Å. Hanngren), Karolinska sjukhuset, Stockholm, Sweden

G. Tornling From the Department of Pathology (Head: G. Moberger), the Department of Plastic Surgery (Head: B. Nylén)and the Department of Thoracic Medicine (Head: Å. Hanngren), Karolinska sjukhuset, Stockholm, Sweden

G. Unge From the Department of Pathology (Head: G. Moberger), the Department of Plastic Surgery (Head: B. Nylén)and the Department of Thoracic Medicine (Head: Å. Hanngren), Karolinska sjukhuset, Stockholm, Sweden

Abstract

The effect of dipyridamole (Persantin) on the survival of experimental skin flaps was studied. In controls 39% of the skin flaps area survived. Intraperitoneal injection of dipyridamole 4 mg/kg twice daily starting four hours preoperatively increased the surviving area with 18%. This increase is statistically significant (p>0.05). The improved survival could be due to the vasodilatory action of the drug and/or proliferation of small bloodvessels induced by the drug.

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Effect of Dipyridamole on the Survival of Experimental Critical Skin Flaps

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Effect of Dipyridamole on the Survival of Experimental Critical Skin Flaps

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