The Elimination of Alpha₂-Macroglobulin Complexes From the Arthritic Joint

Lars Ekerot Department of Hand Surgery (Head: O. Eiken), the Department of Clinical Chemistry (Head: C. B. Laurell), the Department of Experimental Research (Head: S. E. Bergentz), Allmänna sjukhuset, Malmö, Sweden, and the Department of Pathology (Head: F. Koch), Herlev Hospital, Denmark

Kjell Ohlsson Department of Hand Surgery (Head: O. Eiken), the Department of Clinical Chemistry (Head: C. B. Laurell), the Department of Experimental Research (Head: S. E. Bergentz), Allmänna sjukhuset, Malmö, Sweden, and the Department of Pathology (Head: F. Koch), Herlev Hospital, Denmark

Fritz Rank Department of Hand Surgery (Head: O. Eiken), the Department of Clinical Chemistry (Head: C. B. Laurell), the Department of Experimental Research (Head: S. E. Bergentz), Allmänna sjukhuset, Malmö, Sweden, and the Department of Pathology (Head: F. Koch), Herlev Hospital, Denmark

Abstract

A phagocytic uptake of labeled elastase-$aL₂-macroglobulin complexes by macrophage-like synovial lining cells was demonstrated in rheumatoid arthritics. The appearance and distribution of these phagocytically active cells were similar to those containing immunoreactive $aL₂-macroglobulin. It was concluded that these deposits represented phagocytosed $aL₂-macroglobulin complexes and that the elimination of complexes from the arthritic joint at least partly was effected via local phagocytosis.

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The Elimination of Alpha₂-Macroglobulin Complexes From the Arthritic Joint

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The Elimination of Alpha₂-Macroglobulin Complexes From the Arthritic Joint