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Abstract
The influence of periosteal transplants on irradiated bone cavities was studied in ten adult rabbit hind legs. The left hind legs were irradiated with a single X-ray dose of 20 Gy one week before operation. The right hind leg was used as a control. Radiological, histological and biochemical findings were recorded for specimens obtained 8 and 12 weeks after operation. Non-irradiated periosteal transplants on irradiated bone cavities induced more rapid and intense mature bone formation than irradiated periosteal transplants on the same areas. Ossification of bone cavities occurred even more rapidly, when neither the bone nor the transplant had been irradiated. These results indicate that a free periosteal transplant enhances ossification on irradiated bone cavities, whereas ossification may be inhibited or delayed after radiation therapy. A similar effect on diseased human mandibular bone has been observed in our clinical trials.