Natural Killer Cell Activity Following Thermal Injury

M. Jira Departments of Medicine I (Head J. Strejcek) and Plastic Surgery (Head M. Fara), Burn Centre, Faculty Hospital and Medical School, Charles University, Prague, Czechoslovakia

V. Polacek Departments of Medicine I (Head J. Strejcek) and Plastic Surgery (Head M. Fara), Burn Centre, Faculty Hospital and Medical School, Charles University, Prague, Czechoslovakia

J. Strejcek Departments of Medicine I (Head J. Strejcek) and Plastic Surgery (Head M. Fara), Burn Centre, Faculty Hospital and Medical School, Charles University, Prague, Czechoslovakia

M. Fara Departments of Medicine I (Head J. Strejcek) and Plastic Surgery (Head M. Fara), Burn Centre, Faculty Hospital and Medical School, Charles University, Prague, Czechoslovakia

R. Konigova Departments of Medicine I (Head J. Strejcek) and Plastic Surgery (Head M. Fara), Burn Centre, Faculty Hospital and Medical School, Charles University, Prague, Czechoslovakia

Abstract

The role of natural killer cell activity in immunosurveillance following thermal injury remains unknown. We utilize a chromium-51-release assay of K562 targets to monitor NK activity. NK activity of peripheral blood mononuclear cells of severely burned patients (BSA >20%) was determined once a week until the convalescence period was completed. From the second week after thermal injury, impairment of NK activity was demonstrated, but the differences did not reach statistical significance. However, a correlation was found between decline of NK activity and incidences of septic complications. Surprisingly, no decline in NK activity was observed in the first week after thermal injury.

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Natural Killer Cell Activity Following Thermal Injury

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Natural Killer Cell Activity Following Thermal Injury

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