The Effect of Zinc Oxide on Staphylococcus Aureus and Polymorphonuclear Cells in a Tissue Cage Model

Bo Sunzel Departments of Oral Surgery, Umed University Hospital, Umeä, Sweden

Jerzy Lasek Departments of Pathology, Umed University Hospital, Umeä, Sweden; Departments of Nutritional Research, Umed University Hospital, Umeä, Sweden

Thor Söderberg Departments of Hand and Plastic Surgery, Umed University Hospital, Umeä, Sweden

Theodor Elmros Departments of Dermatology, Umed University Hospital, Umeä, Sweden

Göran Hallmans Departments of Pathology, Umed University Hospital, Umeä, Sweden

Stig Holm Department of Clinical Bacteriology, Umed University Hospital, Umeä, Sweden

Abstract

The effect of zinc oxide on S. aureus (209 P) was studied in steel net tissue cages implanted subcutane ously in guinea pigs and rabbits. Zinc oxide installed in the tissue cages created high, sustained concentrations of zinc in the cage fluid throughout the study. In a concentration of 22 mmol/l zinc oxide reduced viable counts in tissue cage fluid inoculated with S. aureus. No deleterious effect was observed on polymorphonuclear cell function.

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The Effect of Zinc Oxide on Staphylococcus Aureus and Polymorphonuclear Cells in a Tissue Cage Model

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The Effect of Zinc Oxide on Staphylococcus Aureus and Polymorphonuclear Cells in a Tissue Cage Model

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