Changes in the Spinal Terminal Pattern of the Superficial Radial Nerve After A Peripheral Nerve Injury: An Anatomical Study in Cats

Abstract

The occurrence of changes within the spinal cord over a long period after a peripheral nerve injury was investigated in adult cats. The lateral superficial branch of the radial nerve was exposed and transsected unilaterally. In one group the nerve endings were re-approximated with epineural sutures and in the other group the proximal nerve stump was enclosed to prevent regeneration. After a survival period of 4–17 months the same nerve on both sides was exposed to an intra-axonal nerve tracer, lectin-conjugated horseradish peroxidase, to label the nerve terminals within the spinal gray matter by transganglionic transport. The general distribution of the terminal field was almost the same after suturing as after encapsulation of the transsected nerve, except for a slightly more cranial location of the terminal area after suturing compared with the control side. The terminal area comprised laminae I-IV of the fifth cervical to the first thoracic spinal segment, concentrated towards the sixth to eighth cervical segments. This distribution was the same as on the control side, but the experimental and control sides differed in intensity of terminals. There was a loss of terminals throughout the terminal field in both operated groups, but after nerve suture there was some recovery of terminal intensity between 4 and 17 months after the injury.

Key Words:

• spinal cord
• horseradish peroxidase
• nerve injury
• sprouting
• regeneration