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Original Article

Cloning Genes for Non-Syndromal Hearing Impairment

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Pages 271-278 | Published online: 12 Oct 2009
 

Abstract

Over 45 genes that cause autosomal non-syndromic hearing impairment (NSHI) have been localized and many more are predicted to exist. To clone these genes, a number of different strategies can be used. This paper focuses on four general approaches: functional cloning, positional cloning, position-dependent candidate gene cloning, and position-independent candidate gene cloning.

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