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Abstract
Pepsin digests of human post-burn wound tissues grafted with autologous fresh skin showed a significantly lower ratio, 0.37 ± 0.04 (mean ± S.D.), of type III to type I collagen determined by interrupted gel electrophoresis than the ratio, 0.55 ± 0.13, measured in ungrafted wound tissues (p < 0.001). In wounds grafted with frozen skin there was no significant difference from ungrafted wounds, but a significantly higher ratio, 0.46 ± 0.08, than that in wounds grafted with fresh skin (p < 0.001). These results were consistent with the histological features of the wound tissues.