Radioprotection of the Kidney with Degradable Microspheres

A pilot study in the dog with repeated irradiation

R. Tuma Department of Physiology, Temple University School of Medicine, Philadelphia, USA

J. O. Forsberg Department of Surgery, University Hospital, Uppsala, Sweden

S. Graffman Department of Oncology, University Hospital, Uppsala, Sweden

B. Jung Department of Radiophysics, University Hospital, Uppsala, Sweden

P. R. Lynch Department of Physiology, Temple University School of Medicine, Philadelphia, USA

Abstract

The left kidney of 9 dogs was irradiated daily for three days with 300 kVp X-rays. Radioprotection was attempted in 5 of the kidneys by administration of degradable microspheres in the renal artery, immediately before irradiation. Protected kidneys received 3 × 8 or 3 × 12 Gy in midplane dose, unprotected kidneys 3 × 5.2 or 3 × 8 Gy. A protective effect due to induced hypoxia could be demonstrated in creatinine clearance, which was significantly higher in protected than in unprotected kidneys at 7 – 13 weeks after irradiation.

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Radioprotection of the Kidney with Degradable Microspheres

A pilot study in the dog with repeated irradiation

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Radioprotection of the Kidney with Degradable Microspheres

A pilot study in the dog with repeated irradiation

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