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Original Article

The Relationship between the Pharmacokinetics and Pharmacodynamics of Spinal Opioids

Minireview based on a doctoral thesis

Pages 101-120 | Published online: 18 Jan 2010
 

Abstract

Spinal opioids have been used clinically since the late seventies to treat acute, traumatic, obstetric and chronic pain. In this article the influence of the pharmacokinetics on the dynamics of intrathecal and epidural opioid administration are discussed with reference to current knowledge.

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