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Abstract
In this work autoradiography of 14C-5,5-dimethyl-2,4-oxazolidinedione (14C-DMO) was used to trace changes in local cerebral pH in embolized awake rabbits. One hour after i.v. injection of 14C-DMO small cerebral ischemic foci were produced in rabbits by injecting plastic beads into the left heart ventricle under short-acting anaesthesia, and after another hour the animals were put to death and their brains processed for autoradiography of 14C-DMO.