The Effect of Benorylate on Collagen-Induced Platelet Aggregation

Abstract

Benorylate, a new lipid-soluble ester of acety[salicylic acid and N-acetyl-P-aminophenol, which has been reported to cause little or no gastrointestinal bleeding after oral administration and yet to possess an anti-inflammatory effect equal to that of aspirin, was compared with aspirin for its ability to inhibit collagen-induced platelet aggregation. Both benorylate and aspirin, in equimolar doses, inhibit aggregation of human platelets when added in vitro, and after oral administration to rabbits they produce an equal degree of inhibition. It is suggested that the greater gastrointestinal bleeding caused by oral administration of aspirin in contrast to benorylate is, therefore, mediated through a local effect on the gastrointestinal mucosa rather than through interference with platelet function.