Abstract
To determine the reaction of the gastric mucosa to HP 549 (isoxepac) an oxo-dibenz-oxepine derivative of acetic add and new non-steroidal antiphlogistic agent in comparison with standard drugs, 12 healthy volunteers received 3 g of Aspirin®, 150 mg of indomethadn, or 600 mg of HP 549 (isoxepac) hi a double-blind cross-over trial. Before and after each treatment period, all subjects underwent gastroscopy with biopsy of gastric mucosa. The subjects recorded complaints (side effects) before and after each treatment period. Aspirin® produced significantly more gross mucosal changes at endoscopy. There was no significant difference between isoxepac and indomethadn. Both produced very few gastric mucosal changes and there were few subjective complaints.