Immunohistochemical Demonstration of Insulin-like Growth Factor I in Inflammatory Lesions in Wegener's Granulomatosis and Idiopathic Midline Destructive Disease

Abstract

The immunoreactivity of the trophic peptide insulin-like growth factor I (IGF-I; somatomedin C) was mapped in nasal mucosa biopsies from three patients with Wegener's granulomatosis (WG) and one with idiopathic midline destructive disease (IMDD; idiopathic midline granuloma). Strongly increased IGF-I immuno-reactivity restricted to cells bordering and in vessel walls and in granulomas (WG) was demonstrated, while necrotic and noninflammatory areas were negative. Treatment with steroids and cyclophosphamide reduced the IGF-I immunoreactivity. The abnormally increased IGF-I immunoreactivities in WG and IMDD probably reflects the reactive growth processes in diseased tissue and is not thought to be the primary cause of either disease. IGF-I may be formed locally by cells in and close to the vascular walls in areas with active disease resulting in e.g. vascular growth, granuloma formation, and finally vessel obliteration and necrosis. IGF-I is likely to form, possibly in conceit with other trophic factors, a link in the chain of events resulting in the tissue abnormalities in WG and IMDD.

Key Words:

• Wegener's granulomatosis
• idiopathic midline destructive disease
• insulin-like growth factor I
• somatomedin C
• endothelial cells
• vascular wall cells
• trophic factors