Antibodies to Interleukin 2 in Sera of Autoimmune-prone Mice

M. Tabata From the First Department of Internal Medicine, Showa University School of Medicine, J-5–8, Hatanodai, Shinagawa-ku, Tokyo, Japan

K. Kobayashi From the First Department of Internal Medicine, Showa University School of Medicine, J-5–8, Hatanodai, Shinagawa-ku, Tokyo, Japan

S. Kaga From the First Department of Internal Medicine, Showa University School of Medicine, J-5–8, Hatanodai, Shinagawa-ku, Tokyo, Japan

M. Hashimoto From the First Department of Internal Medicine, Showa University School of Medicine, J-5–8, Hatanodai, Shinagawa-ku, Tokyo, Japan

T. Kasama From the First Department of Internal Medicine, Showa University School of Medicine, J-5–8, Hatanodai, Shinagawa-ku, Tokyo, Japan

T. Fukushima From the First Department of Internal Medicine, Showa University School of Medicine, J-5–8, Hatanodai, Shinagawa-ku, Tokyo, Japan

K. Yoshida From the First Department of Internal Medicine, Showa University School of Medicine, J-5–8, Hatanodai, Shinagawa-ku, Tokyo, Japan

N. Yamagata From the First Department of Internal Medicine, Showa University School of Medicine, J-5–8, Hatanodai, Shinagawa-ku, Tokyo, Japan

F. Sekine From the First Department of Internal Medicine, Showa University School of Medicine, J-5–8, Hatanodai, Shinagawa-ku, Tokyo, Japan

I. Ohno From the First Department of Internal Medicine, Showa University School of Medicine, J-5–8, Hatanodai, Shinagawa-ku, Tokyo, Japan

M. Negishi From the First Department of Internal Medicine, Showa University School of Medicine, J-5–8, Hatanodai, Shinagawa-ku, Tokyo, Japan

H. Ide From the First Department of Internal Medicine, Showa University School of Medicine, J-5–8, Hatanodai, Shinagawa-ku, Tokyo, Japan

T. Takahashi From the First Department of Internal Medicine, Showa University School of Medicine, J-5–8, Hatanodai, Shinagawa-ku, Tokyo, Japan

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Abstract

Autoimmune-prone mice spontaneously develop the disease characterized by autoantibodies to a wide variety of antigens. In the present study, we have demonstrated that IgG antibodies to interleukin 2 (IL-2) are to be found in serum of autoimmune mice in association with ageing. These antibodies can neutralize the biological activity of IL-2 and thus play an important role in the etiopathogenesis of autoimmune disease.

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Antibodies to Interleukin 2 in Sera of Autoimmune-prone Mice

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Antibodies to Interleukin 2 in Sera of Autoimmune-prone Mice

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