Structure of Class-I MHC Molecules: HLA-B27 and Disease

Abstract

In this introductory article, the structure and function of HLA class-I molecules is discussed. The differences between HLA-B27 and the other class-I molecules are described. It is suggested that HLA-B27 contributes to autoimmune phenomena, but little is known about the actual autoimmune mechanisms that cause the B27-associated disease.

Key Words:

• HLA-B27
• ankylosing spondylitis
• HLA
• autoimmune disease
• T-cell receptor