Attempt to Show Inhibition by Oxygen in the Modifying Factor Assay

J. R. Archer Bone, Tooth and Biomaterials Group, Bone and Joint Research Unit, London Hospital Medical College, London, United Kingdom

A. Claxson Bone, Tooth and Biomaterials Group, Bone and Joint Research Unit, London Hospital Medical College, London, United Kingdom

A. Edwards Bone, Tooth and Biomaterials Group, Bone and Joint Research Unit, London Hospital Medical College, London, United Kingdom

P. W. Thompson Bone, Tooth and Biomaterials Group, Bone and Joint Research Unit, London Hospital Medical College, London, United Kingdom

Abstract

An Australian laboratory has demonstrated that antibodies to certain strains of enteric bacteria react with cells from HLA-B27-positive patients with a 'modifying factor' (MF) from these bacteria. These observations have proved difficult to reproduce. We investigated the possibility that oxygen inhibits the test by blocking B27, but we were unable to obtain consistent positive results.

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Attempt to Show Inhibition by Oxygen in the Modifying Factor Assay

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Attempt to Show Inhibition by Oxygen in the Modifying Factor Assay

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