Red Cell Na⁺/H⁺ Exchange and B Cell Alloantigen 883 (D8/17) in Patients with Acute Rheumatic Fever and Inactive Rheumatic Heart Disease

W. Koren Internal Diseases Department, N.I. Pirogov Medical University, Moscow, Russia

R. Koldanov Internal Diseases Department, N.I. Pirogov Medical University, Moscow, Russia

I. Postnov Internal Diseases Department, N.I. Pirogov Medical University, Moscow, Russia

E. Morozova Internal Diseases Department, N.I. Pirogov Medical University, Moscow, Russia

I. Zolkina Internal Diseases Department, N.I. Pirogov Medical University, Moscow, Russia

L. Enina Internal Diseases Department, N.I. Pirogov Medical University, Moscow, Russia

N. Shostak Internal Diseases Department, N.I. Pirogov Medical University, Moscow, Russia

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Abstract

The association of Na⁺/H⁺ antiport with 883 alloantigen was studied in patients with rheumatic disease. Simultaneous measurements were made of red cell Na⁺/H⁺ exchange and 883 alloantigen in microlymphocytotoxic test with D8/17 monoclonal antibodies in 20 patients with acute rheumatic fever, 20 patients with inactive rheumatic heart disease, 20 patients with atherosclerotic heart disease (stable anginal syndrome), and 20 healthy subjects. The number of 883(+) B cells and the Na⁺/H⁺ antiport activity were increased in rheumatic fever compared to healthy controls: 24.8 ± 0.4 vs. 11.1 ± 1.0% cells, 431±43 vs 121 ± 12 nmol H⁺ /l cells in min, respectively; p < 0.001; and in patients with rheumatic heart disease compared to patients with atherosclerotic heart disease: 25.7 + 1.8 vs. 9.8 + 1.1% cells, 482 + 73 vs. 124±12 umol H⁺ /l cells in min, respectively; p < 0.001.

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Red Cell Na⁺/H⁺ Exchange and B Cell Alloantigen 883 (D8/17) in Patients with Acute Rheumatic Fever and Inactive Rheumatic Heart Disease

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Red Cell Na+/H+ Exchange and B Cell Alloantigen 883 (D8/17) in Patients with Acute Rheumatic Fever and Inactive Rheumatic Heart Disease

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Red Cell Na⁺/H⁺ Exchange and B Cell Alloantigen 883 (D8/17) in Patients with Acute Rheumatic Fever and Inactive Rheumatic Heart Disease