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Scandinavian Journal of Rheumatology Volume 25, 1996 - Issue 4
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Editorial Article

Thrombosis and Systemic Lupus Erythematosus: The Hopkins Lupus Cohort Perspective

M. Petri Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, USA
Pages 191-193 | Published online: 12 Jul 2009
 
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Abstract

Vascular damage in systemic lupus erythematosus (SLE) occurs through vasculitis, premature atherosclerosis, and hypercoagulability (predominantly due to the antiphospholipid antibody syndrome). In the Hopkins Lupus Cohort, a prospective cohort study, the incidence of thrombosis is 2 per 100 person-years of follow-up. Markers of immune-complex mediated injury (high anti-dsDNA and low C3), atherosclerosis (hypertension, hyperlipidemia, homocysteine) and antiphospholipid antibodies (lupus anticoagulant or anticardiolipin) are independent predictors of thrombosis. Hydroxychloroquine use is protective against future thrombosis.

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Related Research Data

Hydroxychloroquine directly reduces the binding of antiphospholipid antibody–β2-glycoprotein I complexes to phospholipid bilayers
Source: American Society of Hematology
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