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Abstract
Primary objective: To create a system for the acquisition of multi-angle, multifrequency muscle impedance data.
Research design: Device development and preliminary testing.
Methods and procedures: The system presented here employs an interrogating signal composed of multiple tones with frequencies between 10 kHz and 300 kHz. The use of a composite signal makes possible measurement of impedance at multiple frequencies simultaneously. In addition, this system takes impedance measurements at multiple orientations with respect to the muscle fibres by means of an electronically reconfigurable electrode array. The required measurement time is reduced by taking advantage of muscle's linearity with respect to the flow of electrical current.
Main outcomes and results: The system was tested in normal subjects, a patient with amyotrophic lateral sclerosis, and one with inclusion body myositis; unique impedance signatures were identified the two patients.
Conclusions: Early data suggest that this system is capable of high-quality data collection and may detect changes in neuromuscular disease; study of additional normal subjects and patients with a variety of neuromuscular diseases is warranted.
Acknowledgements
This work was supported by CIMIT under U.S. Army Medical Research Acquisition Activity Cooperative Agreement W81XWH-07-2-0011. The information contained herein does not necessarily reflect the position or policy of the Government, and no official endorsement should be inferred. We also thank the Microsystems Technology Laboratories, MIT for use of laboratory equipment.
Declaration of interest: A patent application describing the basic construction of the system has been submitted by the authors' institutions. The authors have no other conflicts to disclose.