Multi-parameter brain tissue microsensor and interface systems: Calibration, reliability and user experiences of pressure and temperature sensors in the setting of neurointensive care

Abstract

The objective was to investigate sensor measurement uncertainty for intracerebral probes inserted during neurosurgery and remaining in situ during neurocritical care. This describes a prospective observational study of two sensor types and including performance of the complete sensor-bedside monitoring and readout system. Sensors from 16 patients with severe traumatic brain injury (TBI) were obtained at the time of removal from the brain. When tested, 40% of sensors achieved the manufacturer temperature specification of 0.1 °C. Pressure sensors calibration differed from the manufacturers at all test pressures in 8/20 sensors. The largest pressure measurement error was in the intraparenchymal triple sensor. Measurement uncertainty is not influenced by duration in situ. User experiences reveal problems with sensor ‘handling’, alarms and firmware. Rigorous investigation of the performance of intracerebral sensors in the laboratory and at the bedside has established measurement uncertainty in the ‘real world’ setting of neurocritical care.

• Brain
• measurement error
• neuromonitoring
• temperature
• uncertainty budget

Acknowledgements

We would like to thank Associate Professor Chen Fun-Gee, National University of Singapore, for his support of this work and also the nurses and doctors of the intensive care unit, National University Hospital Health System, Singapore.