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Review Article

Applications of surface-enhanced Raman scattering in advanced bio-medical technologies and diagnostics

, , , , , , & show all
Pages 155-175 | Received 03 Oct 2013, Accepted 05 Dec 2013, Published online: 27 Jan 2014
 

Abstract

In this review of the literature on surface-enhanced Raman scattering (SERS), we describe recent developments of this technique in the medical field. SERS has developed rapidly in the last few years as a result of the fascinating advancements in instrumentation and the ability to interpret complex Raman data using high-processional, computer-aided programs. This technique, has many advantages over ordinary spectroscopic analytical techniques – such as extremely high sensitivity, molecular selectivity, intense signal and great precision – that can be leveraged to address complex medical diagnostics problems. This review focuses on the SERS-active substrate, as well as major advances in cancer and bacteria detection and imaging. Finally, we present a perspective on anticipated future advancements in SERS techniques to address some of the most critical challenges in the areas of diagnostics, detection, and sensing.

Acknowledgements

The editorial assistance of Dr. Marinelle Ringer is acknowledged.

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