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Hemoglobin
international journal for hemoglobin research
Volume 24, 2000 - Issue 1
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Original Article

A New, Electrophoretically Silent, Fetal Hemoglobin Variant: Hb F-Calabria [Gγ118(GH1)Phe→Leu]

, , , &
Pages 37-44 | Received 22 Sep 1999, Accepted 26 Oct 1999, Published online: 07 Jul 2009
 

Abstract

Hb F-Calabria [Gγ118(GH1)Phe→Leu] is a new fetal hemoglobin variant that was found during routine screening for abnormal hemoglobins in a newborn of Calabrian (Southern Italy) ancestry. the variant chain was identified (acid urea gel elect rophoresis of dissociated globin chains in the presence of Triton X-100, and by reversed phase high performance liquid chromatography) as a slightly hydrophilic Gγ chain. Sequencing of the polymerase chain reaction-amplified exon 3 of the Gγ-globin gene demonstrated the TTC→CTC mutation at codon 118 leading to the Phe→Leu conservative substitution at position GH1. A molecular modeling study supports that the variant might not have clinical implications. This is the 40th example of a Gγ chain variant.

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