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Hemoglobin
international journal for hemoglobin research
Volume 33, 2009 - Issue 5
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PROCEEDINGS 17TH ICOC Shenzhen, PR China, November 2007

The Role of Labile Iron in Kidney Disease and Treatment with Chelation

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Pages 378-385 | Published online: 12 Oct 2009
 

Abstract

There are two major forms of kidney disease: acute renal failure [also referred to as acute kidney injury (AKI)] and chronic kidney disease (CKD). Acute renal failure is an abrupt loss of kidney function within 48 h, whereas CKD is a loss of kidney function greater than 3 months. There is a large amount of experimental evidence for an increase of labile iron in a wide variety of models of kidney disease. Additionally, iron chelators provide protection, indicating an important role of labile iron in these diseases. These observations suggest that iron chelators may provide a new modality of prevention and treatment of kidney disease.

ACKNOWLEDGMENTS

The National Institutes of Health and the Veterans Administration provided funding for the basic science studies reported.

Declaration of Interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this article.

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